The main aim of the QUALITOP project is to develop a European immunotherapy-specific open Smart Digital Platform for personalized prevention and patient management. The use of big data analysis, artificial intelligence and simulation modelling approaches will enable collecting efficiently real-world data to monitor health status and the quality of life of cancer patients given immunotherapy. The project, which is part of the Horizon 2020 Research and Innovation Programme, will have a duration of 4 years (2020-2024).